| 组蛋白去甲基化酶JMJD1A |
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| 引用本文： | 郭晓强,王越甲,沈永青,刘贝,段相林.组蛋白去甲基化酶JMJD1A[J].生命的化学,2011(4). |
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| 作者姓名： | 郭晓强 王越甲 沈永青 刘贝 段相林 |
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| 作者单位： | 解放军白求恩军医学院生化教研室;河北师范大学生命科学院; |
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| 基金项目： | 国家自然科学基金资助项目(38070265); 河北省自然基金项目(C2010000410)资助 |
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| 摘 要： | 组蛋白翻译后修饰可影响特定基因的表达,从而在多个生理过程中发挥重要作用,是当前生命科学领域的研究热点之一。组蛋白去甲基化酶JMJD1A可催化一甲基化和二甲基化的H3K9(H3K9me1/2)去甲基化,通过解除组蛋白抑制效应而调节基因表达。JMJD1A拥有广泛的生物学功能,参与多种生物学过程包括核受体激活、精子生成、能量代谢、低氧调节和癌症发生等。本文就JMJD1A的特征及功能作一综述。
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| 关 键 词： | 组蛋白去甲基化酶 JMJD1A 核受体 低氧 癌症发生 |
Advances in histone demethylase JMJD1A |
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| GUO Xiaoqiang,WANG Yuejia,SHEN Yongqing,LIU Bei,DUAN Xianglin.Advances in histone demethylase JMJD1A[J].Chemistry of Life,2011(4). |
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| Authors: | GUO Xiaoqiang WANG Yuejia SHEN Yongqing LIU Bei DUAN Xianglin |
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| Institution: | GUO Xiaoqiang1,2,WANG Yuejia2,SHEN Yongqing2,LIU Bei2,DUAN Xianglin2 1 Department of Biochemistry,Bethune Military Medical College,Shijiazhuang 050081,China 2 College of Life,Hebei Normal University,Shijiazhuang 050016,China |
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| Abstract: | Histone post-translational modifications can affect specific genes expression,which plays an important role in many physiological processes and is one of the intense research area in current life sciences.Histone demethylase JMJD1A(Jumonji domain-containing protein 1A) regulates gene expression by catalyzingdemethylation of mono-and di-methy H3K9(H3K9me1/2).JMJD1A has important biological functions in many physiological processes,such as nuclear receptor activation,sperm development,energy metabolism,hypoxi... |
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| Keywords: | histone demethylase JMJD1A nuclear receptor hypoxia carcinogenesis |
| 本文献已被 CNKI 等数据库收录！ |
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