| 氧化性低密度脂蛋白与细胞自噬 |
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| 引用本文： | 彭楠,苗俊英,张尚立.氧化性低密度脂蛋白与细胞自噬[J].生命的化学,2011(5). |
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| 作者姓名： | 彭楠 苗俊英 张尚立 |
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| 作者单位： | 山东大学生命科学学院发育生物学研究所; |
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| 摘 要： | 氧化性低密度脂蛋白(oxygenized low density lipoprotein,oxLDL)水平的升高不仅引发动脉粥样硬化,还与癌症等疾病的发生有密切关系。研究发现,高水平的oxLDL在引发细胞凋亡的同时,也诱导多种细胞自噬。本文归纳了oxLDL与血管内皮细胞、乳腺上皮细胞、结肠癌细胞、颗粒细胞和神经细胞自噬关系的最新研究进展。
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| 关 键 词： | 氧化低密度脂蛋白 自噬 LOX-1受体 |
Oxygenized low density lipoprotein and autophagy |
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| Abstract: | High level of oxygenized low density lipoprotein(ox-LDL) increases the risk of suffering atherosclerosis.Also it has a close relationship with colon cancer,breast cancer and cancer of the uterus.Recent researches have indicated that high level of oxLDL reviewed not only induce apoptosis but also trigger autophagy in different type of cells.In this paper we reviewed recent researches on oxLDL-induced autophagy in vascular endothelial,cells thymic epithelial cells,colon cancer cells,granulose cells and nerve ... |
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| Keywords: | oxygenized low density lipoprotein autophagy LOX-1 |
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