| 组蛋白的生物素酰化修饰 |
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| 引用本文： | 王燕飞,鲍宝龙.组蛋白的生物素酰化修饰[J].生命的化学,2011(4). |
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| 作者姓名： | 王燕飞 鲍宝龙 |
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| 作者单位： | 上海海洋大学省部共建水产种质资源发掘与利用教育部重点实验室; |
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| 基金项目： | 上海市教委科研创新重点项目(11ZZ146); 上海市教委重点学科建设项目(S30701)(水生生物学)资助 |
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| 摘 要： | 组蛋白修饰对基因表达的表观遗传学调控起着重要作用。组蛋白生物素酰化修饰是近年来新发现的一种组蛋白修饰,具有重要的生物学功能。有证据表明组蛋白生物素酰化在细胞增殖、DNA修复、维持基因组稳定等方面发挥作用。组蛋白的生物素酰化修饰是由羧化全酶合成酶与组蛋白直接相互作用的结果。本文主要介绍了组蛋白生物素酰化发现的过程,并对近年来在组蛋白生物素酰化催化机制和组蛋白生物素酰化功能方面的研究进展进行了综述,最后对组蛋白生物素酰化研究领域存在的问题进行了探讨。
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| 关 键 词： | 组蛋白生物素酰化 生物素 羧化全酶合成酶 生物素酰胺酶 |
The biological functions of histone biotinylation |
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| WANG Yanfei,BAO Baolong Key Laboratory of Exploration , Utilization of Aquatic Genetic Resources,Shanghai Ocean University,Ministry of Education,Shanghai ,China.The biological functions of histone biotinylation[J].Chemistry of Life,2011(4). |
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| Authors: | WANG Yanfei BAO Baolong Key Laboratory of Exploration Utilization of Aquatic Genetic Resources Shanghai Ocean University Ministry of Education Shanghai China |
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| Institution: | WANG Yanfei,BAO Baolong Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources,Shanghai Ocean University,Ministry of Education,Shanghai 201306,China |
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| Abstract: | Histones are subject to a wide variety of posttranslational modifications.Histone biotinylation,covalent binding of the vitamin biotin to lysine residues in histones,is a novel posttranslational modification.Evidence has been provided that biotinylation of histones plays a role in cell proliferation,gene silencing and cellular response to DNA damage.In this paper,we reviewed biotin metabolism,the mechanism of histone biotinylated by holocarbonxylase synthesis and the physiologic function of histone biotinyl... |
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| Keywords: | histones biotinylation biotin holocarbonxylase synthetase biotinidase |
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