| 束缚蛋白抗HIV机制 |
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| 引用本文： | 肖占沛,郭宏雄,羊海涛.束缚蛋白抗HIV机制[J].生命的化学,2011(4). |
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| 作者姓名： | 肖占沛 郭宏雄 羊海涛 |
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| 作者单位： | 东南大学公共卫生学院;江苏省疾病预防控制中心; |
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| 基金项目： | 江苏省自然科学基金(BK2009432)资助 |
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| 摘 要： | 束缚蛋白(tetherin)是一种具有特殊功能的蛋白质,它可抑制包膜病毒从感染细胞中释放。研究发现,人的束缚蛋白可将新生的HIV-1病毒颗粒固定在细胞表面,同时,它还可以减小HIV-1子代病毒的传染性。本文将主要从分子结构、抗HIV-1病毒的作用机制和在HIV传播中的作用三方面来阐述束缚蛋白抗病毒作用的最新研究进展。
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| 关 键 词： | 束缚蛋白 HIV 骨髓基质细胞抗原2 |
The anti-HIV mechanism of tetherin |
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| XIAO Zhanpei,GUO Hongxiong,YANG Haitao School of Public Health,Southeast University,Nanjing ,China Jiangsu Center for Diseases Prevention , Control,China.The anti-HIV mechanism of tetherin[J].Chemistry of Life,2011(4). |
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| Authors: | XIAO Zhanpei GUO Hongxiong YANG Haitao School of Public Health Southeast University Nanjing China Jiangsu Center for Diseases Prevention Control China |
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| Institution: | XIAO Zhanpei1,GUO Hongxiong2,YANG Haitao2 1School of Public Health,Southeast University,Nanjing 210009,China 2Jiangsu Center for Diseases Prevention and Control,China |
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| Abstract: | Tetherin is a special protein that has the unique ability to restrict the release of enveloped viruses.Tetherin not only retains newborn HIV-1 virions on the plasma membrane of infected cells,but also diminishes the infectivity of these progeny virions.This review focuses on recent work including the molecular structure of tetherin,the molecular antiviral mechanisms and the role in the spread of HIV. |
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| Keywords: | tetherin HIV bone marrow stromal cell antigen 2 |
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