| 虫媒黄病毒亚基因组RNA |
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| 引用本文： | 岳磊,刘然,江振友,秦成峰.虫媒黄病毒亚基因组RNA[J].生命的化学,2010(2). |
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| 作者姓名： | 岳磊 刘然 江振友 秦成峰 |
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| 作者单位： | 军事医学科学院微生物流行病研究所;病原微生物生物安全国家重点实验室;暨南大学医学院微生物与免疫学教研室; |
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| 基金项目： | 国家自然科学基金资助项目(No.30972613)资助 |
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| 摘 要： | 黄病毒是一大科人类致病性的单股正链RNA病毒。黄病毒包括登革病毒、西尼罗脑炎病毒及日本脑炎病毒等成员,主要径通过节肢动物的叮咬进行传播,即为虫媒黄病毒。研究发现,在虫媒黄病毒复制过程中,除病毒基因组正链RNA、互补的负链RNA及两者的杂合RNA分子外,在病毒感染细胞后还能产生一种病毒亚基因组RNA(subgenomic RNA,sgRNA)。近年对这种sgRNA展开了比较多的研究,结果表明,其产生机制与已知的其他病毒sgRNA产生机制并不相同。该sgRNA的产生与虫媒黄病毒基因组3’非编码区所形成的保守二级结构有关,同时宿主核酸酶对其的不完全降解亦有重要作用。虫媒黄病毒基因组3’非编码区中带有多个与病毒复制相关的RNA元件,而sgRNA的发现有助于全面地认识病毒RNA与宿主RNA代谢途径间的相互作用,为最终阐明病毒的致病机制奠定基础。
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| 关 键 词： | 虫媒黄病毒 非编码区 亚基因组RNA |
Arthropod-borne flavivirus subgenomic RNA |
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| Lei Yue,Ran Liu,Zhen-You Jiang,Cheng-Feng Qin State Key Laboratory of Pathogen , Biosecurity.Arthropod-borne flavivirus subgenomic RNA[J].Chemistry of Life,2010(2). |
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| Authors: | Lei Yue Ran Liu Zhen-You Jiang Cheng-Feng Qin State Key Laboratory of Pathogen Biosecurity |
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| Institution: | Lei Yue1,2,Ran Liu1,Zhen-You Jiang,Cheng-Feng Qin1 1State Key Laboratory of Pathogen , Biosecurity,Institute of Microbiology , Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China,2Microbiology , Immunology Department of Medical College,Jinan University,Guangzhou 510632 |
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| Abstract: | Flavivirus is an enormous family of human pathogenic single-strand RNA virus.Some members of genus flavivirus,which includes dengue,Japanese encephalitis and West Nile viruses,are designated as Arthropod-borne Flavivirus.During viral replication,it is generally accepted that besides viral genomic RNA,its complementary negative RNA and the hybrid RNAs of both are generated.At the same time,some studies suggested that a set of small sub-genomic viral RNAs (sgRNAs) were also produced in Arthropod-borne flavivi... |
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| Keywords: | arthropod-borne flavivirus sub-genomic RNA non-coding region |
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