| SVCT与维生素C内稳态的保持 |
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| 引用本文： | 郭晓强,王越甲,刘贝,段相林.SVCT与维生素C内稳态的保持[J].生命的化学,2011(3). |
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| 作者姓名： | 郭晓强 王越甲 刘贝 段相林 |
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| 作者单位： | 解放军白求恩军医学院生化教研室;河北师范大学生命科学院; |
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| 摘 要： | 维生素C(又名抗坏血酸)是一种基本的微量营养素,作为辅助因子参与多个酶促反应,同时还是一种自由基清除剂。维生素C内稳态主要由两种钠离子依赖的维生素C转运蛋白(sodium-dependent vitamin C transporter,SVCT)——SVCT1和SVCT2来保持。SVCT1在内皮系统表达,介导了维生素C的肠吸收和肾脏重吸收;而SVCT2表达广泛,表达于脑、骨骼和其他组织,保护这些组织免遭氧化损伤。SVCT的遗传多态性与癌症的发生密切相关。对SVCT介导的维生素C内稳态的保持机制的研究,可使维生素C更好地应用于临床。
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| 关 键 词： | 维生素C内稳态 钠离子依赖的维生素C转运蛋白(SVCT) 遗传多态性 癌症 |
Sodium-dependent vitamin C transporters and the maintenance of vitamin C homeostasis |
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| GUO Xiaoqiang,WANG Yuejia,LIU Bei,DUAN Xianglin.Sodium-dependent vitamin C transporters and the maintenance of vitamin C homeostasis[J].Chemistry of Life,2011(3). |
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| Authors: | GUO Xiaoqiang WANG Yuejia LIU Bei DUAN Xianglin |
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| Institution: | GUO Xiaoqiang1,2,WANG Yuejia2,LIU Bei2,DUAN Xianglin21Department of Biochemistry,Bethune Military Medical College,Shijiazhuang 050081,China,2College of Life Science,Hebei Normal University,Shijiazhuang 050016 |
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| Abstract: | Vitamin C (L-ascorbic acid) is an essential micronutrient participating in many enzymatic reactions as a cofactor and it also serves as a free radical scavenger. Vitamin C homeostasis is mainly maintained by two sodium-dependent Vitamin C transporters: SVCT1 and SVCT2. The SVCT1 gene is expressed in the epithelial systems, and its encoding protein is involved in intestinal absorption and renal reabsorption of vitamin C. SVCT2 exists in metabolically active tissues including brain, skeletal and muscle in ord... |
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| Keywords: | vitamin C homeostasis sodium-dependent vitamin C transporters genetic variation cancer |
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