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RNA干扰在疾病治疗上的应用
引用本文:朱海林,刘秀明,李巍,杜美丽,江莺,李海燕,李校堃.RNA干扰在疾病治疗上的应用[J].生命的化学,2011(1).
作者姓名:朱海林  刘秀明  李巍  杜美丽  江莺  李海燕  李校堃
作者单位:吉林农业大学生物反应器与药物开发教育部工程研究中心;吉林农业大学生命科学学院;吉林农业大学中药材学院;
基金项目:国家高技术研究发展计划(863计划)项目(No.2007AA-100503); 吉林省科技发展计划重点项目(No.20070922); 高等学校科技创新工程重大项目培育资金项目(No.70S018)资助
摘    要:RNA干扰(RNA interference,RNAi)是一种双链RNA分子在mRNA水平上引发的特异性基因沉默现象。RNAi在基因治疗方面表现出了光明的前景,已成功地应用于多种疾病的临床治疗。本文主要介绍了RNAi在疾病治疗上的应用及研究进展。

关 键 词:RNA干扰  siRNA药物  应用  

Application of RNA interference in the treatment of diseases
ZHU Hailin,LIU Xiuming,LI Wei,DU Meili,JIANG Ying,LI Haiyan,LI Xiaokun Ministry of Education Engineering Research Center of Bioreactor , Pharmaceutical Development,Jilin Agricultural University,Changchun ,China,College of Life Sciences,College of Chinese Medicinal Material.Application of RNA interference in the treatment of diseases[J].Chemistry of Life,2011(1).
Authors:ZHU Hailin    LIU Xiuming  LI Wei  DU Meili  JIANG Ying    LI Haiyan  LI Xiaokun Ministry of Education Engineering Research Center of Bioreactor  Pharmaceutical Development  Jilin Agricultural University  Changchun  China  College of Life Sciences  College of Chinese Medicinal Material
Institution:ZHU Hailin1,2,LIU Xiuming1,LI Wei1,DU Meili1,JIANG Ying1,3,LI Haiyan1,LI Xiaokun1 1Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development,Jilin Agricultural University,Changchun 130118,China,2College of Life Sciences,3College of Chinese Medicinal Material
Abstract:RNA interference (RNAi) is double-stranded RNA molecules, which can induce the silence of specific genes at mRNA level. RNAi has a bright perspective in gene therapy, and has been successfully applied to clinical treatment of many diseases. This paper mainly introduces the research progress and application of RNAi in the treatment of diseases.
Keywords:RNA interference  siRNA drug  application  
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