调控肺部炎症消退的内源性介质

炎症反应是宿主重要防御机制之一。慢性炎症或过度炎症反应可导致严重的肺部疾病,如哮喘、急性呼吸窘迫综合征等。新近研究表明炎症消退是一个主动过程,炎症的及时消退是防止炎症过强及走向慢性化的关键环节。因此,调控炎症消退的内源性介质成为新的研究热点。促进炎症消退内源性介质的发现不仅为肺部疾病研究提供新视野,也为全新的促炎症消退治疗策略防治肺部疾病提供理论依据。

Research progress of endogenous mediators regulate lung inflammation resolution

Acute inflammation in the lung is fundamentally important to host defence, however chronic or excessive inflammation leads to serious lung diseases such as asthma, and acute respiratory distress syndrome. Recent studies showed that the resolution of inflammation was an active process and the timely resolution was the key step to prevent inflammation from being chronic. Therefore, endogenous mediators that participate in promoting the resolution of inflammation are becoming a hotspot. It provides not only ne...