| BDNF—TrkB信号通路与焦虑障碍的产生 |
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| 引用本文： | 林玉,张瑞桐,兰明,张天娥,闫智勇.BDNF—TrkB信号通路与焦虑障碍的产生[J].生命的化学,2013(6):668-672. |
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| 作者姓名： | 林玉 张瑞桐 兰明 张天娥 闫智勇 |
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| 作者单位： | [1]西南交通大学生命科学与工程学院,成都610031 [2]成都中医药大学基础医学院,成都611137 |
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| 基金项目： | 国家科技重大专项“十一五”计划（2009ZX09103-370） |
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| 摘 要： | BDNF-TrkB信号通路对情绪产生、认知功能和记忆能力都有重要的影响，主要通过PI3-K途径和Ras-MAP激酶途径调节神经元的再生、凋亡及重建。近年来的研究表明，BDNF基因型及其表达量和TrkB受体表达的异常与焦虑障碍的产生有非常密切的关系。本文综述了近年来BDNF-TrkB信号通路及其与焦虑障碍产生的联系等方面的研究进展。
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| 关 键 词： | 脑源性神经营养因子 酪氨酸激酶受体B 信号通路 焦虑障碍 |
Relationship between BDNF-TrkB signaling pathway and the generation of anxiety disorders |
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| LIN Yu,ZHANG Ruitong,LAN Mingl,ZHANG Tian＇e,YAN Zhiyong.Relationship between BDNF-TrkB signaling pathway and the generation of anxiety disorders[J].Chemistry of Life,2013(6):668-672. |
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| Authors: | LIN Yu ZHANG Ruitong LAN Mingl ZHANG Tian＇e YAN Zhiyong |
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| Institution: | l＊ ( School of College of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 2School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China) |
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| Abstract: | BDNF-TrkB signaling pathway has important influence on emotion production, cognitive function and memory ability. BDNF regulates neuronal regeneration, apoptosis and reconstruction through PI3-K pathway and Ras-MAP kinase pathway. Recent studies have suggested that the genotype of BDNF and the abnormal expression of BDNF and TrkB have a very close relationship with the generation of anxiety disorders. In this paper, the relationship between BDNF-TrkB signaling pathway and the generation of anxiety disorders will be reviewed. |
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| Keywords: | brain-derived neurotrophic factor （BDNF） tyrosine kinase receptor B （TrkB） signalingpathway anxiety disorder |
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