| PI3K/Akt信号通路的调控与肿瘤血管生成 |
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| 引用本文： | 费洪荣,王凤泽.PI3K/Akt信号通路的调控与肿瘤血管生成[J].生命的化学,2010(1). |
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| 作者姓名： | 费洪荣 王凤泽 |
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| 作者单位： | 泰山医学院药学院;泰山医学院生物科学系; |
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| 摘 要： | 肿瘤对人类的生存危害极大,恶性肿瘤的治疗一直是世界性的难题。肿瘤血管生成是肿瘤赖以生长、转移的基础,受多种因子的调节。目前发现有多条信号网络参与调控肿瘤血管生成,PI3K/Akt是其中比较重要的一条信号传导途径,该通路与肿瘤的发生发展密切相关。本文介绍了PI3K/Akt信号通路的结构组成与活性调控,并重点阐述PI3K/Akt信号途径与肿瘤血管生成的关系。
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| 关 键 词： | 磷脂酰肌醇3-激酶(PI3K) Akt/PKB 信号通路 血管生成 |
Activation PI3K/Akt pathway in regulating tumor angiogenesis |
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| Hong-Rong Fei,Feng-Ze Wang College of Pharmacology,Tai\'an ,China.Activation PI3K/Akt pathway in regulating tumor angiogenesis[J].Chemistry of Life,2010(1). |
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| Authors: | Hong-Rong Fei Feng-Ze Wang College of Pharmacology Tai\'an China |
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| Institution: | Hong-Rong Fei1,Feng-Ze Wang2 1College of Pharmacology,Tai\'an 271016,China 2Department of Physiology,Taishan Medical University,China |
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| Abstract: | The complex process of angiogenesis,critical to the growth,invasion,and metastasis of human tumors,is tightly regulated by numerous signaling networks.The abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/Akt (PKB) pathway has been validated by epidemiological and experimental studies as an essential step toward the initiation and maintenance of human tumors.This article provides some insights into the structure and activation of PI3K/Akt pathway.Elucidating the correlation between PI3K/AKT pa... |
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| Keywords: | phosphatidylinositol 3-kinase (PI3K) Akt/PKB signaling pathway tumor angiogenesis |
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