Sox9基因的结构、功能及进化

Sox9基因是继SRY基因之后人们发现的第一个具有内含子的Sox家族成员。在Genebank中可查的Sox9基因序列共671个,广泛分布于哺乳动物和鸟类直至水母等低等动物。近年来的研究发现,Sox9基因的功能呈现多样性,该基因在发育过程中参与性别的决定、软骨的形成以及神经系统和胰腺的形成,另外Sox9基因在肿瘤发生中也有一定的作用。本文从Sox9基因的结构、功能以及进化等方面进行了综述,为进一步研究Sox9基因提供参考资料。

Sox9 gene： structure, function and evolution

Sox9 is the first member ofSox gene family which has intron fragments after the discovery of SRYgene. About 671 Sox9 gene sequences are recorded in the Genebank, which are widely distributed in many species from mammals and bird to coelenterate. Sox9 is a multifunctional gene which takes part in sex determination, chondrogenesis, formation of nervous system and pancreas. Furthermore, this gene can also play roles in oncogenesis. This paper reviews the research progress of the structure, function and evolution of Sox9, to provide references for further study on Sox9 gene.