GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells |
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| Authors: | Raffaella Di Lisi Anne Picard Simonetta Ausoni Stefano Schiaffino |
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| Institution: | (1) Department of Biomedical Sciences, University of Padova, Padova, Italy;(2) CNR Institute of Neurosciences, University of Padova, Padova, Italy;(3) Venetian Institute of Molecular Medicine, Padova, Italy |
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| Abstract: | Background We reported previously that the cardiac troponin I (cTnI) promoter drives cardiac-specific expression of reporter genes in
cardiac muscle cells and in transgenic mice, and that disruption of GATA elements inactivates the cTnI promoter in cultured
cardiomyocytes. We have now examined the role of cTnI promoter GATA elements in skeletal muscle cells. |
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