N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination |
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| Authors: | Valery N Urakov Igor A Valouev Natalia V Kochneva-Pervukhova Anna N Packeiser Alexander Yu Vishnevsky Oleg O Glebov Vladimir N Smirnov Michael D Ter-Avanesyan |
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| Institution: | (1) Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia;(2) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997, Russia;(3) MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK |
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| Abstract: | Background Termination of translation in eukaryotes requires two release factors, eRF1, which recognizes all three nonsense codons and
facilitates release of the nascent polypeptide chain, and eRF3 stimulating translation termination in a GTP-depended manner.
eRF3 from different organisms possess a highly conservative C region (eRF3C), which is responsible for the function in translation
termination, and almost always contain the N-terminal extension, which is inessential and vary both in structure and length.
In the yeast Saccharomyces cerevisiae the N-terminal region of eRF3 is responsible for conversion of this protein into the aggregated and functionally inactive
prion form. |
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