Enzyme electrode for aromatic compounds exploiting the catalytic activities of microperoxidase-11 |
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| Authors: | Yarman Aysu Badalyan Artavazd Gajovic-Eichelmann Nenad Wollenberger Ulla Scheller Frieder W |
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| Institution: | aFraunhofer Institute for Biomedical Engineering IBMT, D-14476 Potsdam, Germany;bInstitute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Golm, Germany |
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| Abstract: | Microperoxidase-11 (MP-11) which has been immobilised in a matrix of chitosan-embedded gold nanoparticles on the surface of a glassy carbon electrode catalyzes the conversion of aromatic substances. This peroxide-dependent catalysis of microperoxidase has been applied in an enzyme electrode for the first time to indicate aromatic compounds such as aniline, 4-fluoroaniline, catechol and p-aminophenol. The electrode signal is generated by the cathodic reduction of the quinone or quinoneimine which is formed in the presence of both MP-11 and peroxide from the substrate. The same sensor principle will be extended to aromatic drugs. |
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| Keywords: | Microperoxidase-11 Nanoparticles p-Aminophenol Aniline Catechol 4-Fluoroaniline Biosensors |
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