| 苦参碱的提取分离及对小鼠的毒性研究 |
| |
| 引用本文： | 张宏利,杨清娥,杨学军,王明春,卜书海,韩崇选.苦参碱的提取分离及对小鼠的毒性研究[J].西北植物学报,2005,25(8):1649-1652. |
| |
| 作者姓名： | 张宏利 杨清娥 杨学军 王明春 卜书海 韩崇选 |
| |
| 作者单位： | 西北农林科技大学,林学院,陕西杨陵,712100 |
| |
| 基金项目： | 国家“十五”科技攻关课题（2001BA509B07-2-02）;国家林业局重点项目（2002-20） |
| |
| 摘 要： | 采用酸性乙醇提取、乙醚萃取、硅胶柱层析分离等方法从苦参中分离到苦参碱单体.以小鼠为实验动物进行毒性测定,小鼠的死亡主要集中在48h内,48h后无小鼠的死亡现象.小鼠对苦参碱的耐受量大于30mg.k-g1,小于140mg.k-g1,致死中量LD50为64.01mg.kg-1,回归方程Y=-3.2370+4.5602X,LD50标准误差SE=6.14.适口性的测定表明,苦参碱对小鼠有较好的适口性,可以作为杀鼠剂使用.
|
| 关 键 词： | 苦参碱 提取分离 小鼠 毒性 |
| 文章编号： | 1000-4025（2005）08-1649-04 |
| 收稿时间： | 01 12 2005 12:00AM |
| 修稿时间： | 2005-01-12 |
Matrine Extraction and Isolation, and Toxicity to Mus musculus |
| |
| ZHANG Hong-li,YANG Qing-er,YANG Xue-jun,WANG Ming-chun,BU Shu-hai,HAN Chong-xuan.Matrine Extraction and Isolation, and Toxicity to Mus musculus[J].Acta Botanica Boreali-Occidentalia Sinica,2005,25(8):1649-1652. |
| |
| Authors: | ZHANG Hong-li YANG Qing-er YANG Xue-jun WANG Ming-chun BU Shu-hai HAN Chong-xuan |
| |
| Institution: | ZHANG Hong-li,YANG Qing-er,YANG Xue-jun,WANG Ming-chun,BU Shu-hai,HAN Chong-xuan~* |
| |
| Abstract: | Matrine was extracted from Sophora flavescens Ait. with acidic ethanol or aether, and isolated by silica gel column chromatograph. The toxicity of matrine was tested on Mus musculus. Mus musculus death mainly occurred within 48 hours after testing and no Mus musculus death took place beyond 48 hours after the testing.The maximum lethal dosage of matrine to Mus musculus ranged between 30 mgkg~(-1) and 140 mgkg~(-1) and the median lethal dosage of matrine (LD_(50)) stod at 64.01 mgkg~(-1). The regression equation of matrine LD_(50) was Y=-3.237 0 + 4.560 2 X with the LD_(50) standard error=6.14. The palatability testing revealed that matrine had a good palatability to Mus musculus and thus could be used as a rodenticide. |
| |
| Keywords: | matrine extraction and isolation Mus musculus toxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《西北植物学报》浏览原始摘要信息 |
| 点击此处可从《西北植物学报》下载免费的PDF全文 |
|
