On the interactions of catalase with subcellular structure |
| |
Authors: | Michael Pegg Denis Crane Colin Masters |
| |
Institution: | (1) Division of Science and Technology, Griffith University, 4111 Brisbane, Australia;(2) Present address: Victorian College of Pharmacy, 381 Royal Parade, 3052 Parkville, Victoria, Australia |
| |
Abstract: | The interaction of mouse liver catalase with subcellular membranes was studied, and an ionic interaction with a variety of membranes, including those derived from the microsomes, was observed. The interaction with microsomal membranes was found to be abolished by pre-treatment of catalase with neuraminidase, indicating a functional significance for catalase-bound sialic acid. Catalase activity was found to be enhanced when bound to membranes, and evidence for a weak association of catalase with peroxisomal structure in mouse liver was also obtained. It is concluded that mouse liver catalase has a capacity to bind to a variety of subcellular membranes in vivo and that this interaction may be consistent with a general protective role for the enzyme, as well as being compatible with a model of peroxisomal biogenesis which involves the interaction of catalase with microsomal membranes.Abbreviations LGF
Large Granule Fraction |
| |
Keywords: | catalase interactions membranes sialic acid protective role |
本文献已被 SpringerLink 等数据库收录! |
|