Occurrence of oxidative stress during myocardial reperfusion |
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Authors: | Prof R Ferrari C Ceconi S Curello A Cargnoni F De Giuli O Visioli |
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Institution: | (1) Cattedra di Cardiologia, Universita' degli Studi di Brescia, Spedali Civili, P. le Spedali Civili, 1, 25100 Brescia, Italy |
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Abstract: | Reperfusion, without doubt, is the most effective way to treat the ischaemic myocardium. Late reperfusion may however cause further damage. Myocardial production of oxygen free radicals above the neutralizing capacity of the myocytes is an important cause of this reperfusion damage. There is evidence that prolonged ischaemia reduces the naturally occurring defence mechanisms of the heart against oxygen free radicals, particularly mitochondrial manganese superoxide dismutase, and intracellular pool of reduced glutathione. Consequently, reperfusion results in a severe oxidative damage, as evidenced by tissue accumulation and release of oxidized glutathione.An oxygen free radical-mediated impairment of mechanical function also occurs during reperfusion of human heart. In fact we observed during surgical reperfusion of coronary artery disease (CAD) patients, a prolonged and sustained release of oxidized glutathione;the degree of oxidative stress was inversely correlated with recovery of mechanical and haemodynamic function. These findings represent the rationale for therapeutic interventions which increase the cellular antioxidant capacities and improve the efficacy of myocardial reperfusion. |
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Keywords: | oxygen free radicals myocardial ischaemia myocardial reperfusion heart damage |
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