Expression of c-Fos in subcutaneous adipose tissue of the fetal pig |
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Authors: | Kichoon Lee Jeff Buhr Gary J Hausman Thomas Wright Roger Dean |
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Institution: | (1) Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, 600 113 Taramani, Madras, India |
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Abstract: | Calcium oxalate crystal growth and aggregation leads to the formation of renal calculi. It is known to be inhibited by several compounds both in vitro and in vivo conditions. The present study highlights the inhibitory potential of sodium pentosan polysulphate (SPP), a semi-synthetic glycosaminoglycan (GAG) on calcium oxalate crystal growth in vitro. Its efficacy was compared with those of known inhibitors like pyrophosphate, heparin and chondroitin-4-sulphate. Of the above compounds pyrophosphate was found to be the most potent inhibitor. Among the GAGs, SPP exhibited 80% inhibitory activity as compared to heparin. A lesser degree of inhibition was observed with chondroitin-4-sulphate. |
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Keywords: | glycosaminoglycans crystal growth pyrophosphate inhibitors |
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