| 水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物 |
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| 引用本文： | 黄火强,谭宁华,曾广智,嵇长久,韩洪金,徐俊驹,张玉梅.水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物[J].云南植物研究,2009,31(2):190-192. |
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| 作者姓名： | 黄火强 谭宁华 曾广智 嵇长久 韩洪金 徐俊驹 张玉梅 |
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| 作者单位： | 1. 中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204;中国科学院研究生院,北京,100049
2. 中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展规划(973计划)，the Foundation of Chinese Academy of Sciences (West Light Program) |
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| 摘 要： | 从水朝阳旋覆花（1nula heliamhus-aquatica）的95％乙醇提取物中分离得到4个麝香草酚类化合物，其中化合物1为新化合物。它们的化学结构通过波谱方法鉴定为：8-hydroxy-9，10-dioxyisopropylidene-thymol（1），10-hydroxy-8，9-dioxyisopropylidene—thymol（2），8-hydroxy-9，10-diisobutyryloxy—thymol（3）和8，10-dihydroxy-9-isobutyryloxy—thymol（4）。肿瘤细胞毒试验结果表明它们在6种肿瘤细胞株上（K562，HT-29，SGC-7901，DU145，MDA-MB-231，U251）显示一定的细胞毒活性，其中化合物2活性最强，它的IC50值为4．20～33．12umol／L。具有细胞毒活性的麝香草酚类化合物是首次在该种植物中发现。
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| 关 键 词： | 水朝阳旋覆花 麝香草酚类化合物 细胞毒活性 |
New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae) |
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| HUANG Huo-Qiang,TAN Ning-Hua,ZENG Guang-Zhi,JI Chang-Jiu,HAN Hong-Jin,XU Jun Ju,ZHANG Yu-Mei.New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae)[J].Acta Botanica Yunnanica,2009,31(2):190-192. |
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| Authors: | HUANG Huo-Qiang TAN Ning-Hua ZENG Guang-Zhi JI Chang-Jiu HAN Hong-Jin XU Jun Ju ZHANG Yu-Mei |
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| Institution: | HUANG Huo-Qiang, TAN Ning-Hua, ZENG Guang-Zhi, JI Chang-Jiu, HAN Hong-Jin, XU Jun-Ju, ZHANG Yu-Mei( 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China) |
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| Abstract: | A new thymol derivative, 8-hydroxy-9,10-dioxyisopropylidene-thymol (1), together with three known thymol derivatives 10-hydroxy-8, 9-dioxyisopropylidene-thymol(2), 8-hydroxy-9, 10-diisobutyryloxy-thymol (3) and 8, 10-dihydroxy-9-isobutyryloxy-thymol (4), was isolated from 95% EtOH extract of the flowers of Inula helianthus-aquatica. Their structures were elucidated on the basis of detailed spectroscopic analysis. These compounds showed cytotoxicities on six cancer cell lines (K562, HT-29, SGC-7901, DU145, MDA-MB-231, U251), and compound 2 is the strongest one with IC50s of 4.20-33.12 μmol/L. This is the first time that the cytotoxic thymol derivatives were isolated from this titled plant. |
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| Keywords: | Inula helianthus-aquatica Thymol derivatives Cytotoxicity |
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