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Design and monitoring of multi‐arm multi‐stage clinical trials |
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| Authors: | Pranab Ghosh Lingyun Liu P Senchaudhuri Ping Gao Cyrus Mehta |
| Institution: | 1. Cytel Inc., Cambridge, Massachusetts, U.S.A.;2. Boston University, Boston, Massachusetts, U.S.A.;3. The Medicines Company, Parsippany, New Jersey, U.S.A.;4. Harvard T.H. Chan School of Public Health, Boston, Massachusetts, U.S.A. |
| Abstract: | |
| Keywords: | Adaptive designs Computation of stopping boundaries Early efficacy stopping Futility stopping Generalized Dunnett tests Group sequential Multiple comparisons Platform designs Spending functions Strong control of type‐1 error |