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Entrapment of herbal extracts into biodegradable microcapsules |
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| Authors: | T N Borodina L D Rumsh S M Kunizhev G B Sukhorukov G N Vorozhtsov B M Feldman A V Rusanova T V Vasil’eva S M Strukova E A Markvicheva |
| Institution: | (1) Stavropol State University, ul. Pushkina 1, Stavropol, 355009, Russia;(2) Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117871, Russia;(3) Queen Mary University of London, London, UK;(4) Federal State Unitary Enterprise “State Scientific Centre “NIOPIK,”, Moscow, Russia;(5) Lomonosov Moscow State University, Moscow, Russia |
| Abstract: | The microcapsules with entrapped herbal water-soluble extracts of plantain Plantago major and calendula Calendula officinalis L. (PCE) were prepared by layer-by-layer (LbL)-adsorption of carrageenan and oligochitosan onto CaCO3 microparticles with their subsequent dissolving after the treatment of EDTA. Entrapment of PCE was performed by using adsorption and co-precipitation techniques. The co-precipitation provided better entrapment of PCE into the carbonate matrix compared to adsorption. In vitro release kinetics (AGJ) was studied using artificial gastric juice. Using the model of acetate ulcer in rats it has been demonstrated that PCE released from the microcapsules accelerates gastric tissue repair. |
| Keywords: | microcapsules herbal extracts oligochitosan carrageenan pepsin biodegradation sustained drug release |
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