Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene,evolution, and immunity |
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| Authors: | B M Pratheek Tapas K Nayak Subhransu S Sahoo Prafulla K Mohanty Soma Chattopadhyay Ntiya G Chakraborty Subhasis Chattopadhyay |
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| Institution: | School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India;1.Department of Zoology, Utkal University, Bhubaneswar, Odisha, India;2.Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, Odisha, India;3.Department of Medicine, University of Connecticut Health Center, Farmington, USA |
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| Abstract: | The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes. Moreover, these nonclassical MHC molecules are known to interact with CD94/NKG2 heterodimeric receptors to induce immune responses and immune regulations. This dual role of Qa-1/HLA-E in terms of innate and adaptive immunity makes them more interesting. This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity. |
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| Keywords: | CD94/NKG2 human leukocyte antigen-E major histocompatibility complex Qa-1 |
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