Remodelling of Neuromuscular Systems During Insect Metamorphosis |
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Authors: | KENT KARLA S; CONSOULAS CHRISTOS; DUNCAN KAREN; JOHNSTON REBECCA M; LUEDEMAN RENE; LEVINE RICHARD B |
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Institution: | Department of Biological Structure and Function, School of Dentistry, Oregon Health Sciences University Portland, Oregon 97201
Division of Neurobiology, University of Arizona Tucson, Arizona 85721 |
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Abstract: | During metamorphosis in the hawkmoth, Manduca sexta, the larvalthoracic legs are replaced by a new set of adult legs that includenew sensory neurons and muscles, and participate in new patternsof locomotor activity. Larval leg motoneurons persist to innervatethe new adult leg muscles, but undergo striking changes in dendriticmorphology that are regulated by the insect steroid, 20-hydroxyecdysone.In the periphery, the motor terminals regress as larval musclesdegenerate, and expand as new adult muscles form from myoblasts.Evidence obtained both in vivo and in vitro suggests that theproliferation of myoblasts during metamorphosis is dependentupon innervation. |
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