A model invalidation-based approach for elucidating biological signalling pathways,applied to the chemotaxis pathway in R. sphaeroides |
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| Authors: | Mark AJ Roberts Elias August Abdullah Hamadeh Philip K Maini Patrick E McSharry Judith P Armitage Antonis Papachristodoulou |
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| Institution: | (1) Control Group, Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX1 3PJ, UK;(2) Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK;(3) Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK;(4) Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK;(5) Mathematical Institute, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK |
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| Abstract: | Background Developing methods for understanding the connectivity of signalling pathways is a major challenge in biological research.
For this purpose, mathematical models are routinely developed based on experimental observations, which also allow the prediction
of the system behaviour under different experimental conditions. Often, however, the same experimental data can be represented
by several competing network models. |
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