Information propagation within the Genetic Network of Saccharomyces cerevisiae |
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| Authors: | Sharif Chowdhury Jason Lloyd-Price Olli-Pekka Smolander Wayne CV Baici Timothy R Hughes Olli Yli-Harja Gordon Chua Andre S Ribeiro |
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| Institution: | 1.Laboratory of Biosystem Dynamics, Computational Systems Biology Research Group, Tampere University of Technology,Tampere,Finland;2.Banting and Best Department of Medical Research,University of Toronto,Toronto,Canada;3.Institute for Systems Biology,Seattle,USA;4.Institute for Biocomplexity and Informatics, University of Calgary,Alberta,Canada;5.Department of Biological Sciences,University of Calgary,Alberta,Canada |
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| Abstract: | Background A gene network's capacity to process information, so as to bind past events to future actions, depends on its structure and
logic. From previous and new microarray measurements in Saccharomyces cerevisiae following gene deletions and overexpressions, we identify a core gene regulatory network (GRN) of functional interactions
between 328 genes and the transfer functions of each gene. Inferred connections are verified by gene enrichment. |
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