Quantitative global studies of reactomes and metabolomes using a vectorial representation of reactions and chemical compounds |
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Authors: | Juan C Triviño Florencio Pazos |
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Institution: | (1) Computational Systems Biology Group, National Centre for Biotechnology (CNB-CSIC), C/Darwin, 3, 28049 Cantoblanco, Madrid, Spain;(2) Genomics Unit, National Centre for Biotechnology (CNB-CSIC), C/Darwin, 3, 28049 Cantoblanco, Madrid, Spain |
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Abstract: | Background Global studies of the protein repertories of organisms are providing important information on the characteristics of the protein
space. Many of these studies entail classification of the protein repertory on the basis of structure and/or sequence similarities.
The situation is different for metabolism. Because there is no good way of measuring similarities between chemical reactions,
there is a barrier to the development of global classifications of "metabolic space" and subsequent studies comparable to
those done for protein sequences and structures. |
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Keywords: | |
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