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Post-translational modifications of protein in response to ionizing radiation |
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| Authors: | Xiaodong Liu Rui Liu Yongheng Bai Heya Jiang Xinxin Fu Shumei Ma |
| Institution: | 1. School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China
NHC Key lab of Radiation Biology, Jilin University, Changchun, Jilin, China Platform for Radiation Protection and Emergency Preparedness of Southern Zhejiang, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China Xiaodong Liu and Rui Liu contributed equally to this work.;2. NHC Key lab of Radiation Biology, Jilin University, Changchun, Jilin, China Xiaodong Liu and Rui Liu contributed equally to this work.;3. Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;4. School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China Platform for Radiation Protection and Emergency Preparedness of Southern Zhejiang, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China;5. School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China |
| Abstract: | Based on central dogma of genetics, protein is the embodiment and executor of genetic function, post-translational modifications (PTMs) of protein are particularly important and involved in almost all aspects of cell biology and pathogenesis. Studies have shown that ionizing radiation (IR) alters gene expression much more profoundly and a broad variety of cell-process pathways, lots of proteins are modified and activated. Our understanding of the protein in response to ionizing radiation is steadily increasing. Among the various biological processes known to induce radioresistance, PTMs have attracted marked attention in recent years. The present review summarizes the latest knowledge about how PTMs response to ionizing radiation and pathway analysis were conducted. The data provided insights into biological effects of IR and contributing to the development of novel IR-based strategies. |
| Keywords: | acetylation glycosylation ionizing radiation methylation phosphorylation post-translational modifications ubiquitination |