Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis |
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| Authors: | David A Hughes Martin Jastroch Mark Stoneking and Martin Klingenspor |
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| Institution: | (1) Department of Evolutionary Genetics, Max-Planck-Institute for Evolutionary Anthropology, Leipzig, Germany;(2) Department of Animal Physiology, Philipps-Universit?t Marburg, Faculty of Biology, Marburg, Germany;(3) Molecular Nutritional Medicine, Technische Universit?t M?nchen, Else Kr?ner-Fresenius Center, Freising-Weihenstephan, Germany |
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| Abstract: | Background Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians. UCP1
is responsible for uncoupling mitochondrial proton transport from the production of ATP, thereby dissipating heat; it is essential
for non-shivering thermogenesis (NST) in mammalian BAT. UCP1 orthologs have been identified in non-Eutherian mammals, fish
and amphibians. Yet, UCP1 has a unique function in Eutherians in that it is necessary in the production of heat (NST). As
such, this study aims to determine the evolutionary mode of UCP1 in Eutherians, where there is clear evidence of UCP1-dependent
NST in BAT. |
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