Evolutionary and functional relationships within the DJ1 superfamily |
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Authors: | Sourav?Bandyopadhyay Email author" target="_blank">Mark?R?CooksonEmail author |
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Institution: | (1) Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892, USA |
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Abstract: | Background Inferences about protein function are often made based on sequence homology to other gene products of known activities. This
approach is valuable for small families of conserved proteins but can be difficult to apply to large superfamilies of proteins
with diverse function. In this study we looked at sequence homology between members of the DJ-1/ThiJ/PfpI superfamily, which
includes a human protein of unclear function, DJ-1, associated with inherited Parkinson's disease. |
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Keywords: | |
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