Molecular evolution of the three short PGRPs of the malaria vectors <Emphasis Type="Italic">An</Emphasis>opheles <Emphasis Type="Italic">gambiae</Emphasis> and <Emphasis Type="Italic">Anopheles arabiensis</Emphasis>in East Africa |
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| Authors: | Cristina Mendes Rute Felix Ana-Margarida Sousa Joana Lamego Derek Charlwood Virgílio E do Rosário João Pinto Henrique Silveira |
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| Institution: | 1.Centro de Malária e outras Doen?as Tropicais, UEI Malária, Instituto de Higiene e Medicina Tropical,Universidade Nova de Lisboa,Lisbon,Portugal;2.DBL - Centre for Health Research and Development, Faculty of Life,Fredriksberg,Denmark |
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| Abstract: | Background Immune responses to parasites, which start with pathogen recognition, play a decisive role in the control of the infection
in mosquitoes. Peptidoglycan recognition proteins (PGRPs) are an important family of pattern recognition receptors that are
involved in the activation of these immune reactions. Pathogen pressure can exert adaptive changes in host genes that are
crucial components of the vector's defence. The aim of this study was to determine the molecular evolution of the three short
PGRPs (PGRP-S1, PGRP-S2 and PGRP-S3) in the two main African malaria vectors - Anopheles gambiae and Anopheles arabiensis. |
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