The effect of natural selection on the performance of maximum parsimony |
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Authors: | Dehua Hang Eric Torng Charles Ofria Thomas M Schmidt |
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Institution: | (1) Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA;(2) Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA |
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Abstract: | Background Maximum parsimony is one of the most commonly used and extensively studied phylogeny reconstruction methods. While current
evaluation methodologies such as computer simulations provide insight into how well maximum parsimony reconstructs phylogenies,
they tell us little about how well maximum parsimony performs on taxa drawn from populations of organisms that evolved subject
to natural selection in addition to the random factors of drift and mutation. It is clear that natural selection has a significant impact on Among Site Rate Variation (ASRV) and the rate of accepted substitutions; that is, accepted mutations do not occur with uniform probability along the
genome and some substitutions are more likely to occur than other substitutions. However, little is know about how ASRV and
non-uniform character substitutions impact the performance of reconstruction methods such as maximum parsimony. To gain insight
into these issues, we study how well maximum parsimony performs with data generated by Avida, a digital life platform where
populations of digital organisms evolve subject to natural selective pressures. |
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