Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates |
| |
Authors: | Sameer S Chopra Hiroshi Watanabe Tao P Zhong Dan M Roden |
| |
Institution: | (1) Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;(2) Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;(3) Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA |
| |
Abstract: | Background Action potential generation in excitable cells such as myocytes and neurons critically depends on voltage-gated sodium channels.
In mammals, sodium channels exist as macromolecular complexes that include a pore-forming alpha subunit and 1 or more modulatory
beta subunits. Although alpha subunit genes have been cloned from diverse metazoans including flies, jellyfish, and humans,
beta subunits have not previously been identified in any non-mammalian species. To gain further insight into the evolution
of electrical signaling in vertebrates, we investigated beta subunit genes in the teleost Danio rerio (zebrafish). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|