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Evolution of the leukotoxin promoter in genus Mannheimia |
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| Authors: | Jesper Larsen Anders G Pedersen Robert L Davies Peter Kuhnert Joachim Frey Henrik Christensen Magne Bisgaard John E Olsen |
| Institution: | 1. Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Stigb?jlen 4, DK-1870, Frederiksberg C, Denmark 2. Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, Building 208, DK-2800, Lyngby, Denmark 3. Glasgow Biomedical Research Centre, Institute of Biomedical and Life Sciences, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK 4. Institute of Veterinary Bacteriology, University of Berne, L?nggass-Strasse 122, CH-3012, Berne, Switzerland |
| Abstract: | BackgroundThe Mannheimia species encompass a wide variety of bacterial lifestyles, including opportunistic pathogens and commensals of the ruminant respiratory tract, commensals of the ovine rumen, and pathogens of the ruminant integument. Here we present a scenario for the evolution of the leukotoxin promoter among representatives of the five species within genus Mannheimia. We also consider how the evolution of the leukotoxin operon fits with the evolution and maintenance of virulence. |
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