Carbazole–azine based fluorescence ‘off–on’ sensor for selective detection of Cu2+ and its live cell imaging |
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| Authors: | Denzil Britto Christopher Leslee Sekar Karuppannan Karmegam Muthu Vengaian Sivaraman Gandhi Singaravadivel Subramanian |
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| Institution: | 1. Department of Chemistry, Anna University – University College of Engineering, Dindigul, India;2. Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India;3. Department of Chemistry, SSM Institute of Engineering and Technology, Dindigul, India |
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| Abstract: | A new carbazole–azine based fluorescent sensor was synthesized and characterized. The selectivity of the sensor for Cu2+ over other counter ions in a dimethyl sulfoxide/H2O mixture was shown through enhancement in fluorescence – an off to on transformation. The specificity of the probe towards Cu2+ was evident in ultraviolet/visible, fluorescence, Fourier transform infrared and mass studies. Application of the probe in the cell imaging and cytotoxicity of living cells is illustrated. |
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| Keywords: | azine carbazole cell imaging copper ion fluorescence |
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