Ethanolic extracts of Euphorbia and other ethnobotanical species as inhibitors of human tumour cell growth |
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| Authors: | LC Whelan MF Ryan |
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| Institution: | Department of Zoology, University College Dublin, Belfield, Dublin, Ireland. |
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| Abstract: | Ethanolic extracts of 20 plant species, selected from the ethnobotanical literature, were analysed for their pharmacological potential as antineoplastic agents against the HEp-2 cell line. Psoralea corylifolia and E. grandidens were the most efficacious species eliciting IC50 values of 22 microg/ml and 57 microg/ml respectively. Psoralea corylifolia, additionally tested against lung carcinoma (A549) cells gave an IC50 value of 68 microg/ml. Such data would justify a search for active compounds from this species. |
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| Keywords: | antineoplastic activity A549 HEp-2 plant extracts |
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