Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice |
| |
Authors: | N Egashira M Yuzurihara N Hattori I Sakakibara A Ishige |
| |
Institution: | Medicinal Evaluation Laboratories, Tsumura & Co., Yoshiwara, Ami-machi Inashiki-gun, Ibaraki, Japan. |
| |
Abstract: | We investigated the effect of Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang), a Japanese herbal medicine, and found that 1000 mg/kg p.o. improved the scopolamine-induced impairment of passive avoidance response in mice. Further, the same dose of Ninjin-yoei-to enhanced oxotremorine-induced tremors in mice. The water extract of Polygalae radix, one of the constituent herbs of Ninjin-yoei-to, at a dose of 100 mg/kg significantly improved the scopolamine-induced impairment of passive avoidance response and enhanced oxotremorine-induced tremors in mice. Moreover, the enhancement of oxotremorine-induced tremors by Ninjin-yoei-to (1000 mg/kg) and Polygalae radix (100 mg/kg) was completely antagonized by pretreatment of scopolamine hydrobromide (0.5 mg/kg). These results suggest that Ninjin-yoei-to may improve the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system and that Polygalae radix may be involved in the action of Ninjin-yoei-to. |
| |
Keywords: | Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) Polygalae radix memory scopolamine passive avoidance performance |
本文献已被 ScienceDirect 等数据库收录! |
|