Anti-inflammatory activity of shikonin derivatives from Arnebia hispidissima. |
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Authors: | B Singh M K Sharma P R Meghwal P M Sahu S Singh |
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Institution: | Department of Botany, University of Rajasthan, Jaipur, India. |
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Abstract: | Arnebia hispidissima ethanolic extract, after chromatography, yielded a number of shikonin derivatives, which were identified as arnebin-5, arnebin-6, teracryl shikonin, arnebinone and acetyl shikonin. All these compounds were firstly reported from this plant species and evaluated to the anti-inflammatory activity of ethanolic extract and isolated shikonin derivatives, models with carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The observed results indicated that pre-treatment with arnebinone significantly inhibited the carrageenan-induced paw edema and also suppressed the development of chronic arthritis induced by CFA. |
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