Histopathology changes in the rainbow trout (Onchorhyncus mykiss) consuming boric acid supplemented fish fodder |
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| Institution: | 1. Department of Fisheries and Diseases, Faculty of Veterinary Medicine, Aksaray University, Turkey;2. Department of Veterinary Pathology, Faculty of Veterinary Medicine, Aksaray University, Turkey;3. Department of Veterinary Histology and Embryology, Faculty of Veterinary Medicine, Aksaray University, Turkey;1. Clinical Medical College, Dali University, Dali, Yunnan, China;2. Affiliated Hospital of Guizhou Medical University, Guiyang, China;3. Department of Oncology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China;4. Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China;1. School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China;2. Guizhou Orthopedics Hospital, Guiyang, 550007, China;1. Key Laboratory of Trace Element Nutrition of National Health Commission of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Beijing 100050, China;2. Animal Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100050, China;1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran;3. Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran;1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan;2. Surface and Nano Analysis Research Group, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, 1-1-1 Higashi Tsukuba, Ibaraki 305-8565, Japan;3. Department of Applied Chemistry, School of Engineering, Tokyo Denki University, 5 Senju-Asahi-cho, Adachi, Tokyo 120-8551, Japan;1. Department of Food Science and Engineering, School of Food and Drug, Luoyang Normal University, Luoyang, 471934, China;2. Beijing Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China;3. Cancer Institute, Fudan University Cancer Hospital and Cancer Metabolism Laboratory, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China |
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| Abstract: | ObjectiveEven though boron (B), as a trace micronutrient, occurs in natural waters and organisms, its high concentration could cause harmful and even toxic for organisms. The aim of present study was to investigate the effects of boric acid (BA) added to feed (0.01%, 0.05%, 0.10%, and 0.20% of B in feed) on Rainbow Trout (Oncorhynchus mykiss) by histopathological methods and compared to the control feed as without B.MethodologyAt the end of the feeding, after weighing the live weight of 9 rainbow trout from each group, tissue fragments were taken from the liver, gill, kidney, skeletal muscle, spleen and brains of fish, which systemic necropsies was done, and were fixed in 10 % buffered formalin solution.ResultsHistopathological examinations revealed degenerative and necrotic changes in the liver, gill, kidney, skeletal muscle, spleen and brain. Hydropic and vacuolar degenerations in liver parenchyma, lamellar edema in the gills, hyaline accumulation in the kidneys, degenerations in the muscles, necrosis in the spleen and hyperemia in the brain were observed in all groups except control group. It was observed that the destruction of boric acid on fish increased depending on the amount of boron supplemented to the feed, and the most effect was in the group fed with 0.20 % boron supplemented feed.ConclusionsThe findings aside from causing pathological changes in all organs in terms of histopathological findings of Boric Acid (BA), the most severe lesions were observed in the liver. |
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| Keywords: | Rainbow trout Boric acid Histopathology |
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