Effect of treatment with silver(I) complex of metronidazole on ocular rosacea: Design and formulation of new silver drug with potent antimicrobial activity |
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| Institution: | 1. Department of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Zeromskiego 113, 90-549 Łódź, Poland;2. Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland;1. Department of Occupational Health, School of Public Health, Shanxi Medical University, China;2. Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, China;3. Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, China;4. Sixth Hospital of Shanxi Medical University (General Hospital of Tisco), China;1. Department of Pediatrics, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku 783-8505, Japan;2. Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku 783-8505, Japan;3. Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku 783-8505, Japan;4. Research Fellow of Japan Society for the Promotion of Science, Japan;1. Department of Family Planning Technical Service, Jining Maternal and Child Health Family Planning Service Center, No.12, Gongxiao Road, Rencheng District, Jining City, Shandong Province, 272000, China;2. Department of Laboratory, Jining Maternal and Child Health Family Planning Service Center, No.12, Gongxiao Road, Rencheng District, Jining City, Shandong Province, 272000, China;1. Laboratory of Microscopy Applied to Reproduction, Department of Histology, Embryology and Cell Biology, Institute of Biological Sciences, Federal University of Goiás, Goiania, Goias 74001970, Brazil;2. Laboratory of Microscopy and Microanalysis, Department of Biology, University Estadual Paulista – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto, Sao Paulo 15054000, Brazil;3. Laboratory of Molecular and Biochemistry Pharmacology, Department of Pharmacology, Institute of Biological Sciences, Federal University of Goiás, Goiania Goias 74001970, Brazil;1. L.B.P.O/Section Endocrinology, Faculty of Biological Sciences, USTHB, BP 32 El-Alia, Bab Ezzouar, 16 111 Algiers, Algeria;2. Departement of Biology, Faculty of Biological Sciences and Agricultural Sciences, UMMTO, 15 000 Tizi-Ouzou, Algeria;3. ETH Zurich, Zurich, Switzerland;4. Iodine Global Network, Ottawa, Ontario, Canada;5. Endocrinology Department, Public Hospital Etablishment IbnZiri, Bologhine, 16090 Algiers, Algeria |
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| Abstract: | BackgroundMetronidazole with well-soluble silver nitrate forms a complex with potent activity (synergism) against bacterial strains and fungi with simultaneous lower side effect than in the case of the two agents administered separately.This study aimed to establish effectiveness in the treatment of ocular rosacea with new formulation of drops and ointment with silver(I) complex of metronidazole.MethodsThree patients suffering from serious ophthalmic complications of acne rosacea were treated with drops and ointments applied 3 times a day for 3 months. The uncorrected visual acuity testing (UCVA), pachymetry as well as subjective and objective tear film assessment were evaluated.ResultsIn all patients, we have improved UCVA as well as objective and subjective evaluation of the tear film parameters. No significant differences in corneal thickness were observed.ConclusionWell soluble silver(I) complex of metronidazole might be an alternative method in ophthalmic complications of acne rosacea treatment. |
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| Keywords: | Silver(I) complex Metronidazole Drops Ointment Ocular rosacea |
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