The influence of macro and trace elements on sperm quality |
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| Institution: | 1. Chair and Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Jordana 19, 41-808 Zabrze, Poland;2. I-st Chair and Clinical Department of Gynecology, Obstetrics and Gynecological Oncology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Batorego 15, 41-902 Bytom, Poland;1. Animal Physiology Division, ICAR-National Institute of Animal Nutrition and Physiology, Bengaluru, Karnataka 560030, India;2. Animal Nutrition Division, ICAR-National Institute of Animal Nutrition and Physiology, Bengaluru, Karnataka 560030, India;1. Bruker-IOCh International Analytical Laboratory Ltd., LLC United Research and Development Centre, 119991 Moscow, Russian Federation;2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;3. Department of Bioenergetics, Institute of Biology, University of Stuttgart, D-70550 Germany;4. Biolitec Research GmbH, 07745 Jena, Germany;5. Centre de Recherche en Automatique de Nancy (CRAN), UMR 7039, Campus Sciences, Université de Lorraine, 54506 Vandoeuvre-lès-Nancy Cedex, France;1. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt;2. Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt;3. Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt;1. IGEVET – Instituto de Genética Veterinaria “Prof. Fernando N. Dulout” (UNLP-CONICET LA PLATA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, calle 60 y 118 s/n, CP 1900, La Plata, Buenos Aires, Argentina;2. Cátedra de Fisiología, Laboratorio de Nutrición Mineral, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, calle 60 y 118 s/n, CP 1900, La Plata, Buenos Aires, Argentina;3. Cátedra de Citología, Histología y Embriología “A”, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, calle 60 y 120 s/n, CP 1900, La Plata, Buenos Aires, Argentina;1. Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China;2. Key Laboratory of Reproduction Regulation of NPFPC, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai 200032, China;3. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China;4. Department of Surgery, Medical College of Shandong University, Jinan 250012, China;5. Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China;6. Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;7. Department of Andrology, Center for Men’s Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China;8. Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China;9. Genesky Biotechnologies Inc., Shanghai 200120, China;10. Center for Reproduction and Genetics, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215002, China;11. Jinghua Hospital, Shenyang Eastern Medical Group, Shenyang 110005, China;12. Research Center for Medical Genomics, Ministry of Education Key Laboratory of Medical Cell Biology, College of Basic Medical Science, China Medical University, Shenyang 110122, China;13. Department of Medical Genetics and Molecular Diagnostic Laboratory, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China |
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| Abstract: | The aim of this study was to examine the association between combined concentrations of macro and trace elements and markers of oxidative stress and antioxidative defense system function together with selected cytokine levels. Based on the combined medians of the seminal plasma levels of calcium, magnesium, zinc, copper, iron, and selenium, the study subjects (88 fertile male volunteers) were divided into the following two subgroups: the Me-L group (low level of metals) and the Me-H group (high level of metals). There was a tendency toward reduced motility in the Me-H group compared to that in the Me-L group. The total protein, albumin, and total oxidation status (TOS) levels were significantly higher in the Me-H group than in the Me-L group. The total superoxide dismutase (SOD), Mn-SOD, and CuZn-SOD, activity in spermatozoa were significantly lower in the Me-H group than in the Me-L group. In seminal plasma, the Mn-SOD activity was significantly higher in the Me-H group, whereas the CuZn-SOD activity was significantly lower. Additionally, the activity levels of glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were lower in the Me-H group. The medians of IL-1β, IL-10, and IL-12 were significantly higher in the Me-H group than in the Me-L group, whereas the medians of IL-2, IL-5, and IL-13 were significantly lower. Higher levels of macro and trace elements in the seminal plasma of fertile males may be associated with decreased motility. Higher levels of the examined metals are associated with elevated oxidative stress accompanied by decreased activities of some of the antioxidant enzymes and increased pro-inflammatory cytokine levels. |
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| Keywords: | Semen Trace elements Oxidative stress Antioxidant enzymes Cytokines |
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