Evaluation of homocysteine,vitamin, and trace element levels in women with gallstones |
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| Institution: | 1. Department of Biochemistry, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey;2. Department of Surgical Medical Sciences, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey;1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Immunology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran;3. University of Debrecen, Medical School Hungary, Egyetem tér 1, Debrecen;4. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;5. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India;7. Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai 602105, India;8. University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India;9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;11. School of Medicine, The University of Western Australia, Perth, Australia;12. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Neurology, General Hospital, Tianjin Medical University, Tianjin 300052, China;2. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China;1. Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Japan;2. School of Medicine, Hirosaki University, Japan;3. Department of Hematology, National Cancer Center Hospital, Japan;4. Center of Innovation, Research Initiatives Organization, Hirosaki University, Japan;1. Environmental Health Sciences Division, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA;2. Saba University School of Medicine, Caribbean, the Netherlands;3. Center for Environmental Occupational Risk Analysis and Management College of Public Health, University of South Florida, Tampa, FL, USA;4. Stantec (Cardno ChemRisk), Boston, MA, USA;5. Saint Francis Hospital and Medical Center; Hartford, CT, USA;6. School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, China;7. Department of Biomedical and Biotechnological Sciences; School of Medicine University of Catania, Via Santa Sofia 97, Catania 95123, Italy;1. Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;4. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;1. Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand, India;2. Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Uttarakhand, India |
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| Abstract: | ObjectiveIt was aimed to examine the changes in homocysteine, folic acid, and vitamin B12, which metabolize homocysteine from the body, and trace elements (zinc, copper, selenium, nickel) that affect the structure of tissues and epithelium in female patients with gallstone disease. Moreover, it was aimed to investigate the contribution of these selected parameters to the etiology of the disease and their usability in treatment according to the findings obtained.Materials and MethodsEighty patients, including 40 female patients (Group I) and 40 completely healthy female individuals (Group II) were included in this study. Serum homocysteine, vitamin B12, folate, zinc, copper, selenium, and nickel levels were evaluated. Electrochemiluminescence immunoassay was used in the analysis of vitamin B12, folic acid, and homocysteine levels, and the ICP-MS method was used in the analysis of trace element levels.ResultsHomocysteine levels in Group I were statistically significantly higher than in Group II. In terms of vitamin B12, zinc, and selenium, Group I levels were found to be statistically significantly lower than group II. There was no statistically significant difference between Group I levels and Group II in terms of copper, nickel, and folate.ConclusionIt was suggested that homocysteine, vitamin B12, zinc, and selenium levels should be determined in patients with gallstone disease and that vitamin B12, which is especially important in the excretion of homocysteine from the body, and zinc and selenium, which prevent the free radical formation and protect from its effects, should be added to the diets of these patients. |
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| Keywords: | Gallstone Trace elements Folate Vitamin B12 |
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