The reproductive toxicity of yttrium nitrate in a two-generation study in Sprague-Dawley rats |
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| Institution: | 1. Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University of the People''s Liberation Army, Shanghai 200433, China;2. Department of Marine Radiation Medicine, Faculty of Naval Medicine, Naval Medical University of the People''s Liberation Army, Shanghai 200433, China;3. School of Basic Medicine, Anhui Medical University, Anhui 230032, China;4. Department of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University of the People''s Liberation Army, Shanghai 200433, China;1. Graduate School of Hebei Medical University, Shijiazhuang 050017, China;2. Hebei Key Laboratory of Reproductive Medicine, Hebei Institute of Reproductive Health Science and Technology, Shijiazhuang 050071, China;1. School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, PR China;2. Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, PR China;1. E?irdir Directorate of Agriculture and Forestry, Isparta, Turkey;2. Afyon Kocatepe University, Bayat Vocational School, Afyonkarahisar, Turkey;3. Bart?n University, Faculty of Science, Department of Molecular Biology and Genetics, Bart?n, Turkey;4. Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Afyonkarahisar, Turkey;1. School of Public Health, Guizhou Medical University, Guian New Region, China;2. The Affiliated Hospital of Guizhou Medical University, Guiyang, China;3. Key Laboratory of Oral Disease Research, School of Stomatology, Zunyi Medical University, Zunyi, China;4. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guian New Region, China;5. Toxicity Testing Center of Guizhou Medical University, Guiyang, China;1. Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt;2. Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University, P.O. Box, 90950, Riyadh 11623, Saudi Arabia;3. Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt |
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| Abstract: | ObjectiveTo evaluate the effects of yttrium nitrate on the development of the parent, offspring and third generation of Sprague-Dawley (SD) rats by using a two-generation reproductive toxicity test.MethodsThe SD rats were randomly divided into 0 mg/kg group, 10.0 mg/kg group, 30.0 mg/kg group and 90.0 mg/kg group according to the different doses of yttrium nitrate administration. The reproductive toxicity of parent, offspring and third generation SD rats were compared.ResultsThe weight gains of F1a female rats and F2a female rats in the low-dose groups were significantly lower than those of the control groups (p < 0.05), the weight gains of F1a male rats in the medium-dose and high-dose groups were significantly lower than those of the control groups (p < 0.05), and the weight gains of F2a male rats in the low-dose, medium-dose and high-dose groups were significantly lower than those of the control groups (p < 0.05). In F0 male rats, the absolute weight and relative weight of the liver in the low-dose, middle-dose, and high-dose groups were significantly lower than those of the control group (p < 0.05). In F1b male rats, the absolute and relative weights of the liver in the medium-dose and high-dose groups were significantly lower than those of the control group (p < 0.05). In F2b male rats, the absolute and relative weights of the liver and spleen of the medium-dose and high-dose groups were significantly lower than those of the control group (p < 0.05). In F2a female rats, the absolute weight and relative weight of oviduct in the high-dose group were significantly lower than those in the control group (p < 0.05). The absolute and relative weights of lung, spleen, brain and uterus of F2b female rats in the high-dose group were higher than those of the control group (p < 0.05). But the pathological test results showed no hepatotoxicity. There was no statistically significant difference in sperm count and sperm motility between male rats in the yttrium nitrate administration groups and the control group (p > 0.05). There was no significant correlation between F0, F1a, F1b, F2a, F2b SD rats' reproductive organ lesions and the dose of yttrium nitrate.ConclusionYttrium nitrate at a dose of 90 mg/kg has no reproductive toxicity to two generations of SD rats, but 30.0 mg/kg dose of yttrium nitrate is toxic to the liver weight of male two generations of SD rats, but no hepatotoxicity. |
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| Keywords: | Yttrium nitrate Reproductive toxicity Hepatotoxicity Two-generation |
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