A pilot study of the effects of chromium picolinate supplementation on serum fetuin-A,metabolic and inflammatory factors in patients with nonalcoholic fatty liver disease: A double-blind,placebo-controlled trial |
| |
| Institution: | 1. Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;2. Nutrition Research Center, Department of Biochemistry & Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Science, Iran;3. Assistant Professor of Internal Medicine, Dept. of Internal Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran;4. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;5. Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran;1. Department of Nutrition, Xin Hua Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, China;2. Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA;3. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;4. Columbia Research Reactor, University of Missouri, Columbia, MO, USA;5. Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA;1. Department of Analytical Chemistry, University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, Belgrade, Serbia;2. Department of Endocrine Surgery, Faculty of Medicine, University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia;3. Center for Endocrine Surgery, Clinical Center of Serbia, Dr Subotića 13, Belgrade, Serbia;4. Department of Biochemistry, University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, Belgrade, Serbia;5. Departments Ecology, Management of Natural Resources and Chemical Engineering, South Ural State University, Lenin Prospect 76, Chelyabinsk, Russia;6. Innovation Center of the Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia |
| |
| Abstract: | BackgroundEvaluating the impact of chromium picolinate supplementation on glycemic status, lipid profile, inflammatory markers and fetuin-A in patients with non-alcoholic fatty liver disease (NAFLD).MethodsIn present research, participants (N = 46) were randomized to (400 mcg/day, n = 23) chromium picolinate and placebo (n = 23) for 3 months.ResultsGlucose indices, and lipid profiles, inflammatory biomarker and fetuin-A were measured before and after the intervention. Chromium reduced triglyceride (TG), atherogenic index of plasma (AIP), very-low-density lipoprotein (VLDL), insulin, homeostatic model assessment for insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), interleukin (IL) -6, tumor necrosis factor-alpha (TNF-α) and fetuin-A significantly compared to placebo group (p < 0.05). Furthermore, chromium significantly increased the quantitative insulin sensitivity check index (QUICKI). There were no significant differences in total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting blood sugar (FBS), Hemoglobin A1c (HbA1C), interleukin (IL)-17 between the two groups (p < 0.05).ConclusionChromium picolinate significantly decreased TG, insulin, HOMA-IR, fetuin-A, the number of inflammatory factors, and increased QUICKI without changing FBS, HbA1C, TC, LDL, HDL, IL-17 levels and liver steatosis intensity in patients with NAFLD. Further studies by examining the effect of different doses of chromium and mechanisms of cellular action, would help further clarify the subject. |
| |
| Keywords: | Chromium Fetuin-A Glucose Lipid Inflammation NAFLD |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
