Quantitative aspects of reactive gliosis: A review |
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| Authors: | Dr W T Norton D A Aquino I Hozumi F -C Chiu C F Brosnan |
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| Institution: | (1) Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461 Bronx, NY;(2) Department of Neuroscience, Albert Einstein College of Medicine, 10461 Bronx, NY;(3) Department of Pathology, Albert Einstein College of Medicine, 10461 Bronx, NY;(4) Present address: Department of Neurology, Brain Research Institute, Niigata University, Asahimachi 1, 951 Niigata, Japan |
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| Abstract: | Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.Special issue dedicated to Dr. Alan N. Davison. |
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| Keywords: | Gliosis astrocytes GFAP brain damage demyelination |
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