Age-Dependent Changes in Calretinin Immunoreactivity and its Protein Level in the Gerbil Hippocampus |
| |
| Authors: | Choong Hyun Lee In Koo Hwang Jung Hoon Choi Ki-Yeon Yoo Ok Kyu Park Sung-Oh Huh Yun Lyul Lee Hyung-Cheul Shin Moo-Ho Won |
| |
| Institution: | (1) Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(2) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(3) Department of Pharmacology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(4) Department of Physiology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(5) Institute of Natural Medicine, Hallym University, Chuncheon, 200-702, South Korea; |
| |
| Abstract: | Calretinin (CR)-immunoreactive interneurons are well known as the interneuron specific interneurons in the hippocampus. CR-immunoreactive
neurons form cellular network and regulate the activity of other GABAergic inhibitory interneurons in the hippocampus. In
the present study, we investigated age-related changes in CR-immunoreactive neurons and protein levels in the gerbil hippocampus
during normal aging. In all subregions of the gerbil hippocampus, the number of CR-immunoreactive neurons was significantly
decreased in the postnatal month 6 (PM 6) group compared to that in the PM 1 group. Thereafter, CR-immunoreactive neurons
were decreased with age. In addition, the number of CR-immunoreactive cells in the subgranular zone were significantly decreased
in the PM 6 group. We also observed that CR protein levels were decreased gradually with age. These results indicate that
both CR immunoreactivity and its protein level were decreased with age in the gerbil hippocampus during normal aging. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
