The Septic Brain |
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Authors: | Emilio L Streck Clarissa M Comim Tatiana Barichello João Quevedo |
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Institution: | 1. Laboratório de Fisiopatologia Experimental, Programa de Pós-gradua??o em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciuma, SC, Brazil 2. Laboratório de Neurociências, Programa de Pós-gradua??o em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciuma, SC, Brazil
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Abstract: | Sepsis is a major disease entity with important clinical implications. Sepsis-induced multiple organ failure is associated
with a high mortality rate in humans and is clinically characterized by pulmonary, cardiovascular, renal and gastrointestinal
dysfunction. Recently, several studies have demonstrated that sepsis survivors present long-term cognitive impairment, including
alterations in memory, attention, concentration and/or global loss of cognitive function. However, the pathogenesis and natural
history of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes
is necessary for the development of effective preventive and therapeutic interventions. This review discusses the clinical
presentation and underlying pathophysiology of the encephalopathy and cognitive impairment associated with sepsis. |
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Keywords: | Sepsis Encephalopathy Cognitive impairment |
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