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Ca2+-Binding S100 Proteins in the Central Nervous System
Authors:Heizmann  Claus W
Institution:(1) Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstr. 75, CH-8032 Zurich, Switzerland
Abstract:A number of neurodegenerative disorders have been attributed to abberrations of intracellular Ca2+ homeostasis regulated by Ca2+-binding proteins. This chapter will focus on the S100B and S100A6 proteins, which are highly expressed in the central nervous system. Their protein structures, localizations, and association with brain pathology as well as their potential use in clinical diagnostics will be discussed.
Keywords:Calcium-binding proteins  Zn2+  neurodegenerative disorders  S100 proteins
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