The 14-3-3 Proteins: Gene,Gene Expression,and Function |
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Authors: | Takahashi Yasuo |
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Institution: | (1) Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata City, 951-8585, Japan;(2) National Saigata Hospital, Ogata, Nakakubikigun, Niigata Prefecture, 949-3116, Japan |
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Abstract: | 14-3-3 Proteins were discovered by Moore and Perez in the soluble extract of bovine brain. These proteins are highly abundant in the brain. In this review 14-3-3 cDNA cloning, nucleotide sequence of 14-3-3 cDNA, the structure of 14-3-3 gene and 14-3-3 gene expression, in situ hybridization of 14-3-3 mRNA in the brain, the function and regulation of 14-3-3 protein, the binding of 14-3-3 protein to other proteins, the effects of 14-3-3 protein on the binding of a protein to other proteins, and the effect on protein kinase, etc., are concisely described. From the recent rapid development of proteom technology, markedly more target proteins of 14-3-3 protein should be discovered. |
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Keywords: | 14-3-3 protein gene gene expression cDNA cloning in situ hybridization function and regulation |
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