Oxidative Stress in Cerebrospinal Fluid of Patients with Aseptic and Bacterial Meningitis |
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Authors: | Charlene Cavalheiro de Menezes Aracélli Gnatta Dorneles Rita Leal Sperotto Marta Medeiros Frescura Duarte Maria Rosa Chitolina Schetinger Vania Lúcia Loro |
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Institution: | 1.Departamento de Química, Centro de Ciências Naturais e Exatas, Programa de Pós-Gradua??o em Bioquímica Toxicológica,Universidade Federal de Santa Maria,Santa Maria,Brazil |
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Abstract: | This study aimed to determine whether patients with aseptic and bacterial meningitis presented alterations in oxidative stress
parameters of cerebrospinal fluid (CSF). A total of 30 patients were used in the research. The CSF oxidative stress status
has been evaluated through many parameters, such as lipid peroxidation through thiobarbituric acid reactive substances (TBARS)
and antioxidant defense systems such as superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and ascorbic acid. TBARS levels, SOD and GST activity increase in aseptic meningitis
and in bacterial meningitis. The ascorbic acid concentration increased significantly in patients with both meningitis types.
The reduced glutathione levels were reduced in CSF of patients with aseptic and bacterial meningitis. In present study we
may conclude that oxidative stress contributes at least in part to the severe neurological dysfunction found in meningitis. |
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Keywords: | Oxidative stress Meningitis Cerebrospinal fluid Antioxidants |
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