Lithium and Valproate Protect Hippocampal Slices Against ATP-induced Cell Death |
| |
Authors: | Leandre Carmen Wilot Andressa Bernardi Rudimar Luiz Frozza Ana Lucilia Marques Helena Cimarosti Christianne Salbego Elizabete Rocha Ana Maria Oliveira Battastini |
| |
Institution: | (1) Departamento de Bioquímica—ICBS, Universidade Federal do Rio Grande do Sul, Av. Ramiro Barcelos, 2600 - anexo, Porto Alegre, RS, CEP 90035-003, Brazil |
| |
Abstract: | Lithium and valproate (VPA) are the most commonly prescribed mood-stabilizing drugs. Recently, several studies have reported
their neuroprotective properties in several models of neural toxicity and, in some pathological conditions, large amounts
of intracellular ATP can be released from damaged cells. In the present study, we investigate the potential neuroprotective
effect of lithium and VPA against ATP-induced cell death in hippocampal slices of adult rats. Acute (in vitro) and chronic (in vivo) treatment at therapeutic doses with lithium or VPA significantly prevent the ATP-induced cell death. Lithium and VPA also
exerted a synergic effect in the prevention of ATP-induced cell death. Moreover, hippocampal slices prepared from rats chronically
treated with lithium or VPA presented a significant reduction in cell death in the presence of cytotoxic extracellular ATP.
Although further investigations are necessary, our results show the neuroprotective effect of lithium and VPA against neuronal
death induced by extracellular ATP, probably through a different pathway, and suggest novel uses of these drugs in neurogenerative
diseases.
L. C. Wilot and A. Bernardi equally contributed by this work. |
| |
Keywords: | Lithium Valproate ATP Cell death Neuroprotection |
本文献已被 PubMed SpringerLink 等数据库收录! |
|